A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
Identifieur interne : 000D64 ( Main/Exploration ); précédent : 000D63; suivant : 000D65A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.
Auteurs : Mark A. Mccormick [États-Unis] ; Joe R. Delaney [États-Unis] ; Mitsuhiro Tsuchiya [États-Unis] ; Scott Tsuchiyama [États-Unis] ; Anna Shemorry [États-Unis] ; Sylvia Sim [États-Unis] ; Annie Chia-Zong Chou [États-Unis] ; Umema Ahmed [États-Unis] ; Daniel Carr [États-Unis] ; Christopher J. Murakami [États-Unis] ; Jennifer Schleit [États-Unis] ; George L. Sutphin [États-Unis] ; Brian M. Wasko [États-Unis] ; Christopher F. Bennett [États-Unis] ; Adrienne M. Wang [États-Unis] ; Brady Olsen [États-Unis] ; Richard P. Beyer [États-Unis] ; Theodor K. Bammler [États-Unis] ; Donna Prunkard [États-Unis] ; Simon C. Johnson [États-Unis] ; Juniper K. Pennypacker [États-Unis] ; Elroy An [États-Unis] ; Arieanna Anies [États-Unis] ; Anthony S. Castanza [États-Unis] ; Eunice Choi [États-Unis] ; Nick Dang [États-Unis] ; Shiena Enerio [États-Unis] ; Marissa Fletcher [États-Unis] ; Lindsay Fox [États-Unis] ; Sarani Goswami [États-Unis] ; Sean A. Higgins [États-Unis] ; Molly A. Holmberg [États-Unis] ; Di Hu [États-Unis] ; Jessica Hui [États-Unis] ; Monika Jelic [États-Unis] ; Ki-Soo Jeong [États-Unis] ; Elijah Johnston [États-Unis] ; Emily O. Kerr [États-Unis] ; Jin Kim [États-Unis] ; Diana Kim [États-Unis] ; Katie Kirkland [États-Unis] ; Shannon Klum [États-Unis] ; Soumya Kotireddy [États-Unis] ; Eric Liao [États-Unis] ; Michael Lim [États-Unis] ; Michael S. Lin [États-Unis] ; Winston C. Lo [États-Unis] ; Dan Lockshon [États-Unis] ; Hillary A. Miller [États-Unis] ; Richard M. Moller [États-Unis] ; Brian Muller [États-Unis] ; Jonathan Oakes [États-Unis] ; Diana N. Pak [États-Unis] ; Zhao Jun Peng [États-Unis] ; Kim M. Pham [États-Unis] ; Tom G. Pollard [États-Unis] ; Prarthana Pradeep [États-Unis] ; Dillon Pruett [États-Unis] ; Dilreet Rai [États-Unis] ; Brett Robison [États-Unis] ; Ariana A. Rodriguez [États-Unis] ; Bopharoth Ros [États-Unis] ; Michael Sage [États-Unis] ; Manpreet K. Singh [États-Unis] ; Erica D. Smith [États-Unis] ; Katie Snead [États-Unis] ; Amrita Solanky [États-Unis] ; Benjamin L. Spector [États-Unis] ; Kristan K. Steffen [États-Unis] ; Bie Nga Tchao [États-Unis] ; Marc K. Ting [États-Unis] ; Helen Vander Wende [États-Unis] ; Dennis Wang [États-Unis] ; K Linnea Welton [États-Unis] ; Eric A. Westman [États-Unis] ; Rachel B. Brem [États-Unis] ; Xin-Guang Liu [République populaire de Chine] ; Yousin Suh [États-Unis] ; Zhongjun Zhou [Hong Kong] ; Matt Kaeberlein [États-Unis] ; Brian K. Kennedy [États-Unis]Source :
- Cell metabolism [ 1932-7420 ] ; 2015.
Descripteurs français
- KwdFr :
- ARN de transfert (génétique), Altération de l'ADN (génétique), Animaux (MeSH), Caenorhabditis elegans (génétique), Complexe protéique du pore nucléaire (génétique), Délétion de gène (MeSH), Facteurs de transcription à motif basique et à glissière à leucines (génétique), Facteurs de transcription à motif basique et à glissière à leucines (métabolisme), Génome (MeSH), Longévité (génétique), Protéines de Saccharomyces cerevisiae (génétique), Protéines de Saccharomyces cerevisiae (métabolisme), Restriction calorique (MeSH), Régulation de l'expression des gènes (génétique), Saccharomyces cerevisiae (génétique), Sérine-thréonine kinases TOR (antagonistes et inhibiteurs), Sérine-thréonine kinases TOR (génétique), Vieillissement (anatomopathologie), Vieillissement (génétique), Vieillissement (métabolisme).
- MESH :
- anatomopathologie : Vieillissement.
- antagonistes et inhibiteurs : Sérine-thréonine kinases TOR.
- génétique : ARN de transfert, Altération de l'ADN, Caenorhabditis elegans, Complexe protéique du pore nucléaire, Facteurs de transcription à motif basique et à glissière à leucines, Longévité, Protéines de Saccharomyces cerevisiae, Régulation de l'expression des gènes, Saccharomyces cerevisiae, Sérine-thréonine kinases TOR, Vieillissement.
- métabolisme : Facteurs de transcription à motif basique et à glissière à leucines, Protéines de Saccharomyces cerevisiae, Vieillissement.
- Animaux, Délétion de gène, Génome, Restriction calorique.
English descriptors
- KwdEn :
- Aging (genetics), Aging (metabolism), Aging (pathology), Animals (MeSH), Basic-Leucine Zipper Transcription Factors (genetics), Basic-Leucine Zipper Transcription Factors (metabolism), Caenorhabditis elegans (genetics), Caloric Restriction (MeSH), DNA Damage (genetics), Gene Deletion (MeSH), Gene Expression Regulation (genetics), Genome (MeSH), Longevity (genetics), Nuclear Pore Complex Proteins (genetics), RNA, Transfer (genetics), Saccharomyces cerevisiae (genetics), Saccharomyces cerevisiae Proteins (genetics), Saccharomyces cerevisiae Proteins (metabolism), TOR Serine-Threonine Kinases (antagonists & inhibitors), TOR Serine-Threonine Kinases (genetics).
- MESH :
- chemical , antagonists & inhibitors : TOR Serine-Threonine Kinases.
- chemical , genetics : Basic-Leucine Zipper Transcription Factors, Nuclear Pore Complex Proteins, RNA, Transfer, Saccharomyces cerevisiae Proteins, TOR Serine-Threonine Kinases.
- genetics : Aging, Caenorhabditis elegans, DNA Damage, Gene Expression Regulation, Longevity, Saccharomyces cerevisiae.
- metabolism : Aging, Basic-Leucine Zipper Transcription Factors, Saccharomyces cerevisiae Proteins.
- pathology : Aging.
- Animals, Caloric Restriction, Gene Deletion, Genome.
Abstract
Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a set of 4,698 viable single-gene deletion strains. Multiple functional gene clusters were identified, and full genome-to-genome comparison demonstrated a significant conservation in longevity pathways between yeast and C. elegans. Among the mechanisms of aging identified, deletion of tRNA exporter LOS1 robustly extended lifespan. Dietary restriction (DR) and inhibition of mechanistic Target of Rapamycin (mTOR) exclude Los1 from the nucleus in a Rad53-dependent manner. Moreover, lifespan extension from deletion of LOS1 is nonadditive with DR or mTOR inhibition, and results in Gcn4 transcription factor activation. Thus, the DNA damage response and mTOR converge on Los1-mediated nuclear tRNA export to regulate Gcn4 activity and aging.
DOI: 10.1016/j.cmet.2015.09.008
PubMed: 26456335
PubMed Central: PMC4862740
Affiliations:
- Hong Kong, République populaire de Chine, États-Unis
- Californie, Washington (État), État de New York
- Seattle
- Université de Washington
Links toward previous steps (curation, corpus...)
Le document en format XML
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Bennett</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Wang, Adrienne M" sort="Wang, Adrienne M" uniqKey="Wang A" first="Adrienne M" last="Wang">Adrienne M. Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Olsen, Brady" sort="Olsen, Brady" uniqKey="Olsen B" first="Brady" last="Olsen">Brady Olsen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Beyer, Richard P" sort="Beyer, Richard P" uniqKey="Beyer R" first="Richard P" last="Beyer">Richard P. Beyer</name><affiliation wicri:level="4"><nlm:affiliation>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Bammler, Theodor K" sort="Bammler, Theodor K" uniqKey="Bammler T" first="Theodor K" last="Bammler">Theodor K. Bammler</name><affiliation wicri:level="4"><nlm:affiliation>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Prunkard, Donna" sort="Prunkard, Donna" uniqKey="Prunkard D" first="Donna" last="Prunkard">Donna Prunkard</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Johnson, Simon C" sort="Johnson, Simon C" uniqKey="Johnson S" first="Simon C" last="Johnson">Simon C. Johnson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pennypacker, Juniper K" sort="Pennypacker, Juniper K" uniqKey="Pennypacker J" first="Juniper K" last="Pennypacker">Juniper K. Pennypacker</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="An, Elroy" sort="An, Elroy" uniqKey="An E" first="Elroy" last="An">Elroy An</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Anies, Arieanna" sort="Anies, Arieanna" uniqKey="Anies A" first="Arieanna" last="Anies">Arieanna Anies</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Castanza, Anthony S" sort="Castanza, Anthony S" uniqKey="Castanza A" first="Anthony S" last="Castanza">Anthony S. Castanza</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Choi, Eunice" sort="Choi, Eunice" uniqKey="Choi E" first="Eunice" last="Choi">Eunice Choi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Dang, Nick" sort="Dang, Nick" uniqKey="Dang N" first="Nick" last="Dang">Nick Dang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Enerio, Shiena" sort="Enerio, Shiena" uniqKey="Enerio S" first="Shiena" last="Enerio">Shiena Enerio</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fletcher, Marissa" sort="Fletcher, Marissa" uniqKey="Fletcher M" first="Marissa" last="Fletcher">Marissa Fletcher</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Fox, Lindsay" sort="Fox, Lindsay" uniqKey="Fox L" first="Lindsay" last="Fox">Lindsay Fox</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Goswami, Sarani" sort="Goswami, Sarani" uniqKey="Goswami S" first="Sarani" last="Goswami">Sarani Goswami</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Higgins, Sean A" sort="Higgins, Sean A" uniqKey="Higgins S" first="Sean A" last="Higgins">Sean A. Higgins</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Holmberg, Molly A" sort="Holmberg, Molly A" uniqKey="Holmberg M" first="Molly A" last="Holmberg">Molly A. Holmberg</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hu, Di" sort="Hu, Di" uniqKey="Hu D" first="Di" last="Hu">Di Hu</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hui, Jessica" sort="Hui, Jessica" uniqKey="Hui J" first="Jessica" last="Hui">Jessica Hui</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Jelic, Monika" sort="Jelic, Monika" uniqKey="Jelic M" first="Monika" last="Jelic">Monika Jelic</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Jeong, Ki Soo" sort="Jeong, Ki Soo" uniqKey="Jeong K" first="Ki-Soo" last="Jeong">Ki-Soo Jeong</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Johnston, Elijah" sort="Johnston, Elijah" uniqKey="Johnston E" first="Elijah" last="Johnston">Elijah Johnston</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kerr, Emily O" sort="Kerr, Emily O" uniqKey="Kerr E" first="Emily O" last="Kerr">Emily O. Kerr</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kim, Jin" sort="Kim, Jin" uniqKey="Kim J" first="Jin" last="Kim">Jin Kim</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kim, Diana" sort="Kim, Diana" uniqKey="Kim D" first="Diana" last="Kim">Diana Kim</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kirkland, Katie" sort="Kirkland, Katie" uniqKey="Kirkland K" first="Katie" last="Kirkland">Katie Kirkland</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Klum, Shannon" sort="Klum, Shannon" uniqKey="Klum S" first="Shannon" last="Klum">Shannon Klum</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kotireddy, Soumya" sort="Kotireddy, Soumya" uniqKey="Kotireddy S" first="Soumya" last="Kotireddy">Soumya Kotireddy</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Liao, Eric" sort="Liao, Eric" uniqKey="Liao E" first="Eric" last="Liao">Eric Liao</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lim, Michael" sort="Lim, Michael" uniqKey="Lim M" first="Michael" last="Lim">Michael Lim</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lin, Michael S" sort="Lin, Michael S" uniqKey="Lin M" first="Michael S" last="Lin">Michael S. Lin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lo, Winston C" sort="Lo, Winston C" uniqKey="Lo W" first="Winston C" last="Lo">Winston C. Lo</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lockshon, Dan" sort="Lockshon, Dan" uniqKey="Lockshon D" first="Dan" last="Lockshon">Dan Lockshon</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Miller, Hillary A" sort="Miller, Hillary A" uniqKey="Miller H" first="Hillary A" last="Miller">Hillary A. Miller</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Moller, Richard M" sort="Moller, Richard M" uniqKey="Moller R" first="Richard M" last="Moller">Richard M. Moller</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Muller, Brian" sort="Muller, Brian" uniqKey="Muller B" first="Brian" last="Muller">Brian Muller</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Oakes, Jonathan" sort="Oakes, Jonathan" uniqKey="Oakes J" first="Jonathan" last="Oakes">Jonathan Oakes</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pak, Diana N" sort="Pak, Diana N" uniqKey="Pak D" first="Diana N" last="Pak">Diana N. Pak</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Peng, Zhao Jun" sort="Peng, Zhao Jun" uniqKey="Peng Z" first="Zhao Jun" last="Peng">Zhao Jun Peng</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pham, Kim M" sort="Pham, Kim M" uniqKey="Pham K" first="Kim M" last="Pham">Kim M. Pham</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pollard, Tom G" sort="Pollard, Tom G" uniqKey="Pollard T" first="Tom G" last="Pollard">Tom G. Pollard</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pradeep, Prarthana" sort="Pradeep, Prarthana" uniqKey="Pradeep P" first="Prarthana" last="Pradeep">Prarthana Pradeep</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pruett, Dillon" sort="Pruett, Dillon" uniqKey="Pruett D" first="Dillon" last="Pruett">Dillon Pruett</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Rai, Dilreet" sort="Rai, Dilreet" uniqKey="Rai D" first="Dilreet" last="Rai">Dilreet Rai</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Robison, Brett" sort="Robison, Brett" uniqKey="Robison B" first="Brett" last="Robison">Brett Robison</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rodriguez, Ariana A" sort="Rodriguez, Ariana A" uniqKey="Rodriguez A" first="Ariana A" last="Rodriguez">Ariana A. Rodriguez</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ros, Bopharoth" sort="Ros, Bopharoth" uniqKey="Ros B" first="Bopharoth" last="Ros">Bopharoth Ros</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Sage, Michael" sort="Sage, Michael" uniqKey="Sage M" first="Michael" last="Sage">Michael Sage</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Singh, Manpreet K" sort="Singh, Manpreet K" uniqKey="Singh M" first="Manpreet K" last="Singh">Manpreet K. Singh</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Smith, Erica D" sort="Smith, Erica D" uniqKey="Smith E" first="Erica D" last="Smith">Erica D. Smith</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Snead, Katie" sort="Snead, Katie" uniqKey="Snead K" first="Katie" last="Snead">Katie Snead</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Solanky, Amrita" sort="Solanky, Amrita" uniqKey="Solanky A" first="Amrita" last="Solanky">Amrita Solanky</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Spector, Benjamin L" sort="Spector, Benjamin L" uniqKey="Spector B" first="Benjamin L" last="Spector">Benjamin L. Spector</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Steffen, Kristan K" sort="Steffen, Kristan K" uniqKey="Steffen K" first="Kristan K" last="Steffen">Kristan K. Steffen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Tchao, Bie Nga" sort="Tchao, Bie Nga" uniqKey="Tchao B" first="Bie Nga" last="Tchao">Bie Nga Tchao</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Ting, Marc K" sort="Ting, Marc K" uniqKey="Ting M" first="Marc K" last="Ting">Marc K. Ting</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Vander Wende, Helen" sort="Vander Wende, Helen" uniqKey="Vander Wende H" first="Helen" last="Vander Wende">Helen Vander Wende</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Wang, Dennis" sort="Wang, Dennis" uniqKey="Wang D" first="Dennis" last="Wang">Dennis Wang</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Welton, K Linnea" sort="Welton, K Linnea" uniqKey="Welton K" first="K Linnea" last="Welton">K Linnea Welton</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Westman, Eric A" sort="Westman, Eric A" uniqKey="Westman E" first="Eric A" last="Westman">Eric A. Westman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Brem, Rachel B" sort="Brem, Rachel B" uniqKey="Brem R" first="Rachel B" last="Brem">Rachel B. Brem</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Liu, Xin Guang" sort="Liu, Xin Guang" uniqKey="Liu X" first="Xin-Guang" last="Liu">Xin-Guang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Suh, Yousin" sort="Suh, Yousin" uniqKey="Suh Y" first="Yousin" last="Suh">Yousin Suh</name><affiliation wicri:level="2"><nlm:affiliation>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong, P.R. China; Department of Genetics, Albert Einstein College of Medicine, New York, NY 10461, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong, P.R. China; Department of Genetics, Albert Einstein College of Medicine, New York, NY 10461</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Hong Kong, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Biochemistry, University of Hong Kong</wicri:regionArea><wicri:noRegion>University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Kaeberlein, Matt" sort="Kaeberlein, Matt" uniqKey="Kaeberlein M" first="Matt" last="Kaeberlein">Matt Kaeberlein</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA. Electronic address: kaeber@uw.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kennedy, Brian K" sort="Kennedy, Brian K" uniqKey="Kennedy B" first="Brian K" last="Kennedy">Brian K. Kennedy</name><affiliation wicri:level="4"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. Electronic address: bkennedy@buckinstitute.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2015">2015</date><idno type="RBID">pubmed:26456335</idno><idno type="pmid">26456335</idno><idno type="doi">10.1016/j.cmet.2015.09.008</idno><idno type="pmc">PMC4862740</idno><idno type="wicri:Area/Main/Corpus">000B67</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000B67</idno><idno type="wicri:Area/Main/Curation">000B67</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000B67</idno><idno type="wicri:Area/Main/Exploration">000B67</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.</title><author><name sortKey="Mccormick, Mark A" sort="Mccormick, Mark A" uniqKey="Mccormick M" first="Mark A" last="Mccormick">Mark A. Mccormick</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Delaney, Joe R" sort="Delaney, Joe R" uniqKey="Delaney J" first="Joe R" last="Delaney">Joe R. Delaney</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Tsuchiya, Mitsuhiro" sort="Tsuchiya, Mitsuhiro" uniqKey="Tsuchiya M" first="Mitsuhiro" last="Tsuchiya">Mitsuhiro Tsuchiya</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Tsuchiyama, Scott" sort="Tsuchiyama, Scott" uniqKey="Tsuchiyama S" first="Scott" last="Tsuchiyama">Scott Tsuchiyama</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Shemorry, Anna" sort="Shemorry, Anna" uniqKey="Shemorry A" first="Anna" last="Shemorry">Anna Shemorry</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Sim, Sylvia" sort="Sim, Sylvia" uniqKey="Sim S" first="Sylvia" last="Sim">Sylvia Sim</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Chou, Annie Chia Zong" sort="Chou, Annie Chia Zong" uniqKey="Chou A" first="Annie Chia-Zong" last="Chou">Annie Chia-Zong Chou</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Ahmed, Umema" sort="Ahmed, Umema" uniqKey="Ahmed U" first="Umema" last="Ahmed">Umema Ahmed</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Carr, Daniel" sort="Carr, Daniel" uniqKey="Carr D" first="Daniel" last="Carr">Daniel Carr</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Murakami, Christopher J" sort="Murakami, Christopher J" uniqKey="Murakami C" first="Christopher J" last="Murakami">Christopher J. Murakami</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Schleit, Jennifer" sort="Schleit, Jennifer" uniqKey="Schleit J" first="Jennifer" last="Schleit">Jennifer Schleit</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Sutphin, George L" sort="Sutphin, George L" uniqKey="Sutphin G" first="George L" last="Sutphin">George L. Sutphin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Wasko, Brian M" sort="Wasko, Brian M" uniqKey="Wasko B" first="Brian M" last="Wasko">Brian M. Wasko</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Bennett, Christopher F" sort="Bennett, Christopher F" uniqKey="Bennett C" first="Christopher F" last="Bennett">Christopher F. Bennett</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Wang, Adrienne M" sort="Wang, Adrienne M" uniqKey="Wang A" first="Adrienne M" last="Wang">Adrienne M. Wang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Olsen, Brady" sort="Olsen, Brady" uniqKey="Olsen B" first="Brady" last="Olsen">Brady Olsen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Beyer, Richard P" sort="Beyer, Richard P" uniqKey="Beyer R" first="Richard P" last="Beyer">Richard P. Beyer</name><affiliation wicri:level="4"><nlm:affiliation>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Bammler, Theodor K" sort="Bammler, Theodor K" uniqKey="Bammler T" first="Theodor K" last="Bammler">Theodor K. Bammler</name><affiliation wicri:level="4"><nlm:affiliation>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Prunkard, Donna" sort="Prunkard, Donna" uniqKey="Prunkard D" first="Donna" last="Prunkard">Donna Prunkard</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Johnson, Simon C" sort="Johnson, Simon C" uniqKey="Johnson S" first="Simon C" last="Johnson">Simon C. Johnson</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pennypacker, Juniper K" sort="Pennypacker, Juniper K" uniqKey="Pennypacker J" first="Juniper K" last="Pennypacker">Juniper K. Pennypacker</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="An, Elroy" sort="An, Elroy" uniqKey="An E" first="Elroy" last="An">Elroy An</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Anies, Arieanna" sort="Anies, Arieanna" uniqKey="Anies A" first="Arieanna" last="Anies">Arieanna Anies</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Castanza, Anthony S" sort="Castanza, Anthony S" uniqKey="Castanza A" first="Anthony S" last="Castanza">Anthony S. Castanza</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Choi, Eunice" sort="Choi, Eunice" uniqKey="Choi E" first="Eunice" last="Choi">Eunice Choi</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Dang, Nick" sort="Dang, Nick" uniqKey="Dang N" first="Nick" last="Dang">Nick Dang</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Enerio, Shiena" sort="Enerio, Shiena" uniqKey="Enerio S" first="Shiena" last="Enerio">Shiena Enerio</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Fletcher, Marissa" sort="Fletcher, Marissa" uniqKey="Fletcher M" first="Marissa" last="Fletcher">Marissa Fletcher</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Fox, Lindsay" sort="Fox, Lindsay" uniqKey="Fox L" first="Lindsay" last="Fox">Lindsay Fox</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Goswami, Sarani" sort="Goswami, Sarani" uniqKey="Goswami S" first="Sarani" last="Goswami">Sarani Goswami</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Higgins, Sean A" sort="Higgins, Sean A" uniqKey="Higgins S" first="Sean A" last="Higgins">Sean A. Higgins</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Holmberg, Molly A" sort="Holmberg, Molly A" uniqKey="Holmberg M" first="Molly A" last="Holmberg">Molly A. Holmberg</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hu, Di" sort="Hu, Di" uniqKey="Hu D" first="Di" last="Hu">Di Hu</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Hui, Jessica" sort="Hui, Jessica" uniqKey="Hui J" first="Jessica" last="Hui">Jessica Hui</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Jelic, Monika" sort="Jelic, Monika" uniqKey="Jelic M" first="Monika" last="Jelic">Monika Jelic</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Jeong, Ki Soo" sort="Jeong, Ki Soo" uniqKey="Jeong K" first="Ki-Soo" last="Jeong">Ki-Soo Jeong</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Johnston, Elijah" sort="Johnston, Elijah" uniqKey="Johnston E" first="Elijah" last="Johnston">Elijah Johnston</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kerr, Emily O" sort="Kerr, Emily O" uniqKey="Kerr E" first="Emily O" last="Kerr">Emily O. Kerr</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kim, Jin" sort="Kim, Jin" uniqKey="Kim J" first="Jin" last="Kim">Jin Kim</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kim, Diana" sort="Kim, Diana" uniqKey="Kim D" first="Diana" last="Kim">Diana Kim</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kirkland, Katie" sort="Kirkland, Katie" uniqKey="Kirkland K" first="Katie" last="Kirkland">Katie Kirkland</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Klum, Shannon" sort="Klum, Shannon" uniqKey="Klum S" first="Shannon" last="Klum">Shannon Klum</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kotireddy, Soumya" sort="Kotireddy, Soumya" uniqKey="Kotireddy S" first="Soumya" last="Kotireddy">Soumya Kotireddy</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Liao, Eric" sort="Liao, Eric" uniqKey="Liao E" first="Eric" last="Liao">Eric Liao</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lim, Michael" sort="Lim, Michael" uniqKey="Lim M" first="Michael" last="Lim">Michael Lim</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lin, Michael S" sort="Lin, Michael S" uniqKey="Lin M" first="Michael S" last="Lin">Michael S. Lin</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lo, Winston C" sort="Lo, Winston C" uniqKey="Lo W" first="Winston C" last="Lo">Winston C. Lo</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Lockshon, Dan" sort="Lockshon, Dan" uniqKey="Lockshon D" first="Dan" last="Lockshon">Dan Lockshon</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Miller, Hillary A" sort="Miller, Hillary A" uniqKey="Miller H" first="Hillary A" last="Miller">Hillary A. Miller</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Moller, Richard M" sort="Moller, Richard M" uniqKey="Moller R" first="Richard M" last="Moller">Richard M. Moller</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Muller, Brian" sort="Muller, Brian" uniqKey="Muller B" first="Brian" last="Muller">Brian Muller</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Oakes, Jonathan" sort="Oakes, Jonathan" uniqKey="Oakes J" first="Jonathan" last="Oakes">Jonathan Oakes</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pak, Diana N" sort="Pak, Diana N" uniqKey="Pak D" first="Diana N" last="Pak">Diana N. Pak</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Peng, Zhao Jun" sort="Peng, Zhao Jun" uniqKey="Peng Z" first="Zhao Jun" last="Peng">Zhao Jun Peng</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pham, Kim M" sort="Pham, Kim M" uniqKey="Pham K" first="Kim M" last="Pham">Kim M. Pham</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pollard, Tom G" sort="Pollard, Tom G" uniqKey="Pollard T" first="Tom G" last="Pollard">Tom G. Pollard</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pradeep, Prarthana" sort="Pradeep, Prarthana" uniqKey="Pradeep P" first="Prarthana" last="Pradeep">Prarthana Pradeep</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Pruett, Dillon" sort="Pruett, Dillon" uniqKey="Pruett D" first="Dillon" last="Pruett">Dillon Pruett</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Rai, Dilreet" sort="Rai, Dilreet" uniqKey="Rai D" first="Dilreet" last="Rai">Dilreet Rai</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Robison, Brett" sort="Robison, Brett" uniqKey="Robison B" first="Brett" last="Robison">Brett Robison</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Rodriguez, Ariana A" sort="Rodriguez, Ariana A" uniqKey="Rodriguez A" first="Ariana A" last="Rodriguez">Ariana A. Rodriguez</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Ros, Bopharoth" sort="Ros, Bopharoth" uniqKey="Ros B" first="Bopharoth" last="Ros">Bopharoth Ros</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Sage, Michael" sort="Sage, Michael" uniqKey="Sage M" first="Michael" last="Sage">Michael Sage</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Singh, Manpreet K" sort="Singh, Manpreet K" uniqKey="Singh M" first="Manpreet K" last="Singh">Manpreet K. Singh</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Smith, Erica D" sort="Smith, Erica D" uniqKey="Smith E" first="Erica D" last="Smith">Erica D. Smith</name><affiliation wicri:level="4"><nlm:affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Snead, Katie" sort="Snead, Katie" uniqKey="Snead K" first="Katie" last="Snead">Katie Snead</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Solanky, Amrita" sort="Solanky, Amrita" uniqKey="Solanky A" first="Amrita" last="Solanky">Amrita Solanky</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Spector, Benjamin L" sort="Spector, Benjamin L" uniqKey="Spector B" first="Benjamin L" last="Spector">Benjamin L. Spector</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Steffen, Kristan K" sort="Steffen, Kristan K" uniqKey="Steffen K" first="Kristan K" last="Steffen">Kristan K. Steffen</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Tchao, Bie Nga" sort="Tchao, Bie Nga" uniqKey="Tchao B" first="Bie Nga" last="Tchao">Bie Nga Tchao</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Ting, Marc K" sort="Ting, Marc K" uniqKey="Ting M" first="Marc K" last="Ting">Marc K. Ting</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Vander Wende, Helen" sort="Vander Wende, Helen" uniqKey="Vander Wende H" first="Helen" last="Vander Wende">Helen Vander Wende</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Wang, Dennis" sort="Wang, Dennis" uniqKey="Wang D" first="Dennis" last="Wang">Dennis Wang</name><affiliation wicri:level="4"><nlm:affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Welton, K Linnea" sort="Welton, K Linnea" uniqKey="Welton K" first="K Linnea" last="Welton">K Linnea Welton</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Westman, Eric A" sort="Westman, Eric A" uniqKey="Westman E" first="Eric A" last="Westman">Eric A. Westman</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Brem, Rachel B" sort="Brem, Rachel B" uniqKey="Brem R" first="Rachel B" last="Brem">Rachel B. Brem</name><affiliation wicri:level="2"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Liu, Xin Guang" sort="Liu, Xin Guang" uniqKey="Liu X" first="Xin-Guang" last="Liu">Xin-Guang Liu</name><affiliation wicri:level="1"><nlm:affiliation>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong, P.R. China.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">République populaire de Chine</country><wicri:regionArea>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong</wicri:regionArea><wicri:noRegion>Guangdong</wicri:noRegion></affiliation></author><author><name sortKey="Suh, Yousin" sort="Suh, Yousin" uniqKey="Suh Y" first="Yousin" last="Suh">Yousin Suh</name><affiliation wicri:level="2"><nlm:affiliation>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong, P.R. China; Department of Genetics, Albert Einstein College of Medicine, New York, NY 10461, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong, P.R. China; Department of Genetics, Albert Einstein College of Medicine, New York, NY 10461</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name><affiliation wicri:level="1"><nlm:affiliation>Department of Biochemistry, University of Hong Kong, Hong Kong.</nlm:affiliation><country xml:lang="fr">Hong Kong</country><wicri:regionArea>Department of Biochemistry, University of Hong Kong</wicri:regionArea><wicri:noRegion>University of Hong Kong</wicri:noRegion></affiliation></author><author><name sortKey="Kaeberlein, Matt" sort="Kaeberlein, Matt" uniqKey="Kaeberlein M" first="Matt" last="Kaeberlein">Matt Kaeberlein</name><affiliation wicri:level="4"><nlm:affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA. Electronic address: kaeber@uw.edu.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Pathology, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author><author><name sortKey="Kennedy, Brian K" sort="Kennedy, Brian K" uniqKey="Kennedy B" first="Brian K" last="Kennedy">Brian K. Kennedy</name><affiliation wicri:level="4"><nlm:affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. Electronic address: bkennedy@buckinstitute.org.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195</wicri:regionArea><placeName><region type="state">Washington (État)</region><settlement type="city">Seattle</settlement></placeName><orgName type="university">Université de Washington</orgName></affiliation></author></analytic><series><title level="j">Cell metabolism</title><idno type="eISSN">1932-7420</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aging (genetics)</term><term>Aging (metabolism)</term><term>Aging (pathology)</term><term>Animals (MeSH)</term><term>Basic-Leucine Zipper Transcription Factors (genetics)</term><term>Basic-Leucine Zipper Transcription Factors (metabolism)</term><term>Caenorhabditis elegans (genetics)</term><term>Caloric Restriction (MeSH)</term><term>DNA Damage (genetics)</term><term>Gene Deletion (MeSH)</term><term>Gene Expression Regulation (genetics)</term><term>Genome (MeSH)</term><term>Longevity (genetics)</term><term>Nuclear Pore Complex Proteins (genetics)</term><term>RNA, Transfer (genetics)</term><term>Saccharomyces cerevisiae (genetics)</term><term>Saccharomyces cerevisiae Proteins (genetics)</term><term>Saccharomyces cerevisiae Proteins (metabolism)</term><term>TOR Serine-Threonine Kinases (antagonists & inhibitors)</term><term>TOR Serine-Threonine Kinases (genetics)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>ARN de transfert (génétique)</term><term>Altération de l'ADN (génétique)</term><term>Animaux (MeSH)</term><term>Caenorhabditis elegans (génétique)</term><term>Complexe protéique du pore nucléaire (génétique)</term><term>Délétion de gène (MeSH)</term><term>Facteurs de transcription à motif basique et à glissière à leucines (génétique)</term><term>Facteurs de transcription à motif basique et à glissière à leucines (métabolisme)</term><term>Génome (MeSH)</term><term>Longévité (génétique)</term><term>Protéines de Saccharomyces cerevisiae (génétique)</term><term>Protéines de Saccharomyces cerevisiae (métabolisme)</term><term>Restriction calorique (MeSH)</term><term>Régulation de l'expression des gènes (génétique)</term><term>Saccharomyces cerevisiae (génétique)</term><term>Sérine-thréonine kinases TOR (antagonistes et inhibiteurs)</term><term>Sérine-thréonine kinases TOR (génétique)</term><term>Vieillissement (anatomopathologie)</term><term>Vieillissement (génétique)</term><term>Vieillissement (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Basic-Leucine Zipper Transcription Factors</term><term>Nuclear Pore Complex Proteins</term><term>RNA, Transfer</term><term>Saccharomyces cerevisiae Proteins</term><term>TOR Serine-Threonine Kinases</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="antagonistes et inhibiteurs" xml:lang="fr"><term>Sérine-thréonine kinases TOR</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Aging</term><term>Caenorhabditis elegans</term><term>DNA Damage</term><term>Gene Expression Regulation</term><term>Longevity</term><term>Saccharomyces cerevisiae</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>ARN de transfert</term><term>Altération de l'ADN</term><term>Caenorhabditis elegans</term><term>Complexe protéique du pore nucléaire</term><term>Facteurs de transcription à motif basique et à glissière à leucines</term><term>Longévité</term><term>Protéines de Saccharomyces cerevisiae</term><term>Régulation de l'expression des gènes</term><term>Saccharomyces cerevisiae</term><term>Sérine-thréonine kinases TOR</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Aging</term><term>Basic-Leucine Zipper Transcription Factors</term><term>Saccharomyces cerevisiae Proteins</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Facteurs de transcription à motif basique et à glissière à leucines</term><term>Protéines de Saccharomyces cerevisiae</term><term>Vieillissement</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Aging</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Caloric Restriction</term><term>Gene Deletion</term><term>Genome</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Délétion de gène</term><term>Génome</term><term>Restriction calorique</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a set of 4,698 viable single-gene deletion strains. Multiple functional gene clusters were identified, and full genome-to-genome comparison demonstrated a significant conservation in longevity pathways between yeast and C. elegans. Among the mechanisms of aging identified, deletion of tRNA exporter LOS1 robustly extended lifespan. Dietary restriction (DR) and inhibition of mechanistic Target of Rapamycin (mTOR) exclude Los1 from the nucleus in a Rad53-dependent manner. Moreover, lifespan extension from deletion of LOS1 is nonadditive with DR or mTOR inhibition, and results in Gcn4 transcription factor activation. Thus, the DNA damage response and mTOR converge on Los1-mediated nuclear tRNA export to regulate Gcn4 activity and aging. </div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">26456335</PMID><DateCompleted><Year>2016</Year><Month>09</Month><Day>06</Day></DateCompleted><DateRevised><Year>2019</Year><Month>10</Month><Day>08</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1932-7420</ISSN><JournalIssue CitedMedium="Internet"><Volume>22</Volume><Issue>5</Issue><PubDate><Year>2015</Year><Month>Nov</Month><Day>03</Day></PubDate></JournalIssue><Title>Cell metabolism</Title><ISOAbbreviation>Cell Metab</ISOAbbreviation></Journal><ArticleTitle>A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging.</ArticleTitle><Pagination><MedlinePgn>895-906</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.cmet.2015.09.008</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S1550-4131(15)00465-9</ELocationID><Abstract><AbstractText>Many genes that affect replicative lifespan (RLS) in the budding yeast Saccharomyces cerevisiae also affect aging in other organisms such as C. elegans and M. musculus. We performed a systematic analysis of yeast RLS in a set of 4,698 viable single-gene deletion strains. Multiple functional gene clusters were identified, and full genome-to-genome comparison demonstrated a significant conservation in longevity pathways between yeast and C. elegans. Among the mechanisms of aging identified, deletion of tRNA exporter LOS1 robustly extended lifespan. Dietary restriction (DR) and inhibition of mechanistic Target of Rapamycin (mTOR) exclude Los1 from the nucleus in a Rad53-dependent manner. Moreover, lifespan extension from deletion of LOS1 is nonadditive with DR or mTOR inhibition, and results in Gcn4 transcription factor activation. Thus, the DNA damage response and mTOR converge on Los1-mediated nuclear tRNA export to regulate Gcn4 activity and aging. </AbstractText><CopyrightInformation>Copyright © 2015 Elsevier Inc. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>McCormick</LastName><ForeName>Mark A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Delaney</LastName><ForeName>Joe R</ForeName><Initials>JR</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsuchiya</LastName><ForeName>Mitsuhiro</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tsuchiyama</LastName><ForeName>Scott</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Shemorry</LastName><ForeName>Anna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sim</LastName><ForeName>Sylvia</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chou</LastName><ForeName>Annie Chia-Zong</ForeName><Initials>AC</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ahmed</LastName><ForeName>Umema</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Carr</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Murakami</LastName><ForeName>Christopher J</ForeName><Initials>CJ</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schleit</LastName><ForeName>Jennifer</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sutphin</LastName><ForeName>George L</ForeName><Initials>GL</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wasko</LastName><ForeName>Brian M</ForeName><Initials>BM</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bennett</LastName><ForeName>Christopher F</ForeName><Initials>CF</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA; Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Adrienne M</ForeName><Initials>AM</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olsen</LastName><ForeName>Brady</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beyer</LastName><ForeName>Richard P</ForeName><Initials>RP</Initials><AffiliationInfo><Affiliation>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bammler</LastName><ForeName>Theodor K</ForeName><Initials>TK</Initials><AffiliationInfo><Affiliation>Department of Occupational and Environmental Health Sciences, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Prunkard</LastName><ForeName>Donna</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Johnson</LastName><ForeName>Simon C</ForeName><Initials>SC</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pennypacker</LastName><ForeName>Juniper K</ForeName><Initials>JK</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>An</LastName><ForeName>Elroy</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Anies</LastName><ForeName>Arieanna</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Castanza</LastName><ForeName>Anthony S</ForeName><Initials>AS</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Choi</LastName><ForeName>Eunice</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dang</LastName><ForeName>Nick</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Enerio</LastName><ForeName>Shiena</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fletcher</LastName><ForeName>Marissa</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Fox</LastName><ForeName>Lindsay</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Goswami</LastName><ForeName>Sarani</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Higgins</LastName><ForeName>Sean A</ForeName><Initials>SA</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Holmberg</LastName><ForeName>Molly A</ForeName><Initials>MA</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hu</LastName><ForeName>Di</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hui</LastName><ForeName>Jessica</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author 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ValidYN="Y"><LastName>Kim</LastName><ForeName>Jin</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kim</LastName><ForeName>Diana</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kirkland</LastName><ForeName>Katie</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Klum</LastName><ForeName>Shannon</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kotireddy</LastName><ForeName>Soumya</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liao</LastName><ForeName>Eric</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lim</LastName><ForeName>Michael</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Michael S</ForeName><Initials>MS</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author 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ValidYN="Y"><LastName>Muller</LastName><ForeName>Brian</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Oakes</LastName><ForeName>Jonathan</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Pak</LastName><ForeName>Diana N</ForeName><Initials>DN</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peng</LastName><ForeName>Zhao Jun</ForeName><Initials>ZJ</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, 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Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Solanky</LastName><ForeName>Amrita</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Spector</LastName><ForeName>Benjamin L</ForeName><Initials>BL</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Steffen</LastName><ForeName>Kristan K</ForeName><Initials>KK</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tchao</LastName><ForeName>Bie Nga</ForeName><Initials>BN</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ting</LastName><ForeName>Marc K</ForeName><Initials>MK</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Vander Wende</LastName><ForeName>Helen</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Dennis</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Molecular and Cellular Biology Program, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Welton</LastName><ForeName>K Linnea</ForeName><Initials>KL</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Westman</LastName><ForeName>Eric A</ForeName><Initials>EA</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brem</LastName><ForeName>Rachel B</ForeName><Initials>RB</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Xin-Guang</ForeName><Initials>XG</Initials><AffiliationInfo><Affiliation>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong, P.R. China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Suh</LastName><ForeName>Yousin</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Aging Research Institute, Guangdong Medical College, Dongguan 523808, Guangdong, P.R. China; Department of Genetics, Albert Einstein College of Medicine, New York, NY 10461, USA.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zhou</LastName><ForeName>Zhongjun</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Biochemistry, University of Hong Kong, Hong Kong.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kaeberlein</LastName><ForeName>Matt</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pathology, University of Washington, Seattle, WA 98195, USA. Electronic address: kaeber@uw.edu.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kennedy</LastName><ForeName>Brian K</ForeName><Initials>BK</Initials><AffiliationInfo><Affiliation>Buck Institute for Research on Aging, 8001 Redwood Boulevard, Novato, CA 94945, USA; Department of Biochemistry, University of Washington, Seattle, WA 98195, USA. 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Wasko</name><name sortKey="Welton, K Linnea" sort="Welton, K Linnea" uniqKey="Welton K" first="K Linnea" last="Welton">K Linnea Welton</name><name sortKey="Westman, Eric A" sort="Westman, Eric A" uniqKey="Westman E" first="Eric A" last="Westman">Eric A. Westman</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Liu, Xin Guang" sort="Liu, Xin Guang" uniqKey="Liu X" first="Xin-Guang" last="Liu">Xin-Guang Liu</name></noRegion></country><country name="Hong Kong"><noRegion><name sortKey="Zhou, Zhongjun" sort="Zhou, Zhongjun" uniqKey="Zhou Z" first="Zhongjun" last="Zhou">Zhongjun Zhou</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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